Sohail Sen comes from a family of musicians who have worked in the film industry and his entry into the film composing world marked the fourth generation of his family to do so.
    His father, Sameer Sen (of the music director duo Dilip Sen – Sameer Sen) has always been a strong influence in his life, as was his paternal grandfather Shri Shambhu Sen's singing (home town sujangarh(churu) rajasthan).
    Sen started learning music at the age of six. He learnt to play the tabla as a child, and then went on to learn various musical instruments including the piano and percussion and rhythm instruments. He learnt classical music from his grandfather Shri Shambhu Sen. He began his career as a music director at the young age of thirteen when he composed the music for a telefilm titled Roshni and for which renowned singer Kavita Krishnamurthy provided playback. He then decided to assist his father for nine years to fine tune his skills as a film composer.